BIOM 421: OSMOTIC ENGINE
EXAMPLES OF USE
Mathematical modelling of the immune response to cancer [1]
Idividual-based model of immune-cancer cell interactions to extend an earlier spatio-temporal model of tumour dormancy
- Examining an individual based model of two immune cell populations interacting with two tumour cell populations
The Molecular Basis of Radial Intercalation during Tissue Spreading in Early Development [2]
Radial intercalation is driven by short-range chemotaxis during epiboly
Deep cells chemotax toward C3-producing superficial cells during Xenopus epiboly
HISTORY
CompuCell3D was originally created in order to model morphogenesis, the process in which cells cluster into patterns which eventually differentiate into organs, muscle, or bone during the embryonic development. The developers were James A. Glazier, Dr. Mark Alber and Dr. Jesus Izaguirre and collaborators at the University of Notre Dame with support from National Science Foundation, Division of Integrative Biology [3]. It uses the Cellular Potts Model, a computational tool designed to model cell behavior and take into account cell migration, clustering, and growth taking adhesive forces, environment sensing as well as volume and surface-area constraints. Although originally designed to model biological cells, Compucell3D can be used to model components or fluids within the cell. The program allows researchers to start with a base model of a cell or cells, and then model the specific behavior or phenomene they are investigating, therefore speeding up the time it takes for simulations to debug [8].